MovDisordV3, Main, Exploration, bibRecord, 001F40

Impaired Insulin Sensitivity and Secretion in Normoglycemic Patients with Spinocerebellar Ataxia Type 1

Identifieur interne : 001F40 ( Main/Exploration ); précédent : 001F39; suivant : 001F41

Impaired Insulin Sensitivity and Secretion in Normoglycemic Patients with Spinocerebellar Ataxia Type 1

Auteurs : Nebojša M. Lalic [Serbie] ; Nataša Dragasevic [Serbie] ; Elka Stefanova [Serbie] ; Aleksandra Jotic [Serbie] ; Katarina Lalic [Serbie] ; Tanja Milicic [Serbie] ; Igor Petrovic [Serbie] ; Marija Macesic [Serbie] ; Vladimir S. Kostic [Serbie]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0446317

Descripteurs français

Pascal (Inist)
- Insulinorésistance, Pathologie du système nerveux, Insuline, Sensibilité, Homme, Ataxie spinocérébelleuse.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Human, Insulin, Insulin resistance, Nervous system diseases, Sensitivity, Spinocerebellar ataxia.

Abstract

We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD-specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA-insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1.

Affiliations:

Serbie

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Le document en format XML

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<author><name sortKey="Petrovic, Igor" sort="Petrovic, Igor" uniqKey="Petrovic I" first="Igor" last="Petrovic">Igor Petrovic</name>
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<term>Spinocerebellar ataxia</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Insulinorésistance</term>
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<term>Homme</term>
<term>Ataxie spinocérébelleuse</term>
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<front><div type="abstract" xml:lang="en">We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD-specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA-insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1.</div>
</front>
</TEI>
<affiliations><list><country><li>Serbie</li>
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<tree><country name="Serbie"><noRegion><name sortKey="Lalic, Nebojsa M" sort="Lalic, Nebojsa M" uniqKey="Lalic N" first="Nebojša M." last="Lalic">Nebojša M. Lalic</name>
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<name sortKey="Dragasevic, Natasa" sort="Dragasevic, Natasa" uniqKey="Dragasevic N" first="Nataša" last="Dragasevic">Nataša Dragasevic</name>
<name sortKey="Jotic, Aleksandra" sort="Jotic, Aleksandra" uniqKey="Jotic A" first="Aleksandra" last="Jotic">Aleksandra Jotic</name>
<name sortKey="Kostic, Vladimir S" sort="Kostic, Vladimir S" uniqKey="Kostic V" first="Vladimir S." last="Kostic">Vladimir S. Kostic</name>
<name sortKey="Lalic, Katarina" sort="Lalic, Katarina" uniqKey="Lalic K" first="Katarina" last="Lalic">Katarina Lalic</name>
<name sortKey="Macesic, Marija" sort="Macesic, Marija" uniqKey="Macesic M" first="Marija" last="Macesic">Marija Macesic</name>
<name sortKey="Milicic, Tanja" sort="Milicic, Tanja" uniqKey="Milicic T" first="Tanja" last="Milicic">Tanja Milicic</name>
<name sortKey="Petrovic, Igor" sort="Petrovic, Igor" uniqKey="Petrovic I" first="Igor" last="Petrovic">Igor Petrovic</name>
<name sortKey="Stefanova, Elka" sort="Stefanova, Elka" uniqKey="Stefanova E" first="Elka" last="Stefanova">Elka Stefanova</name>
</country>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Impaired Insulin Sensitivity and Secretion in Normoglycemic Patients with Spinocerebellar Ataxia Type 1

Impaired Insulin Sensitivity and Secretion in Normoglycemic Patients with Spinocerebellar Ataxia Type 1

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri